Irene Bozzoni Selected Research

RNA-Binding Protein FUS

1/2020	FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
1/2017	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.
7/2015	ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons.
7/2014	An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry.
12/2012	FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment.

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Irene Bozzoni Research Topics

Disease

11	Neoplasms (Cancer) 01/2022 - 05/2007
10	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2020 - 07/2002
9	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 12/2012
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2016 - 05/2007
3	Carcinogenesis 01/2017 - 12/2008
3	Neuroblastoma 01/2015 - 05/2007
3	Muscular Diseases (Myopathy) 02/2011 - 07/2002
2	Disease Progression 01/2021 - 05/2011
2	Atrophy 11/2020 - 08/2013
2	Sarcoma (Soft Tissue Sarcoma) 01/2019 - 12/2012
2	Medulloblastoma 05/2017 - 02/2009
2	Leukemia 09/2016 - 08/2009
1	Alveolar Rhabdomyosarcoma 01/2021
1	Muscular Atrophy (Muscle Atrophy) 11/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Myotonic Dystrophy (Dystrophia Myotonica) 04/2019
1	Neurodevelopmental Disorders 10/2018
1	Inflammation (Inflammations) 01/2017
1	Multiple Sclerosis 01/2017
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017
1	Pathologic Processes 01/2017
1	Frontotemporal Dementia (Semantic Dementia) 01/2017
1	Carcinoma (Carcinomatosis) 07/2015
1	Fibrosis (Cirrhosis) 08/2013
1	Ischemia 08/2013
1	Respiratory Tract Infections (Respiratory Tract Infection) 10/2011
1	Respiratory Tract Diseases (Respiratory Tract Disease) 10/2011
1	Neuromuscular Diseases (Neuromuscular Disease) 05/2011
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2010
1	Hematologic Neoplasms (Hematological Malignancy) 08/2009
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 11/2006
1	Retinal Degeneration 11/2006
1	Blindness (Hysterical Blindness) 11/2006

Drug/Important Bio-Agent (IBA)

15	MicroRNAs (MicroRNA)IBA 01/2021 - 05/2007
9	DystrophinIBA 08/2013 - 07/2002
5	RNA (Ribonucleic Acid)IBA 11/2020 - 01/2017
5	RNA-Binding Protein FUSIBA 01/2020 - 12/2012
4	Circular RNAIBA 01/2022 - 04/2017
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2015
3	Long Noncoding RNAIBA 05/2017 - 01/2015
2	Messenger RNA (mRNA)IBA 01/2022 - 04/2019
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020 - 01/2019
2	Glutamic Acid (Glutamate)FDA Link 10/2018 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 05/2017 - 05/2011
2	Competitive Endogenous RNAIBA 05/2017 - 09/2016
2	Protein Isoforms (Isoforms)IBA 02/2009 - 05/2007
1	locked nucleic acidIBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Untranslated RNA (Noncoding RNA)IBA 01/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2020
1	RNA Splicing FactorsIBA 01/2020
1	RibonucleoproteinsIBA 01/2019
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 10/2018
1	propionic acid (potassium propionate)IBA 10/2018
1	Ribonucleases (Ribonuclease)IBA 01/2017
1	Uridylate-Specific EndoribonucleasesIBA 01/2017
1	CCAAT-Enhancer-Binding ProteinsIBA 07/2015
1	Mutant Proteins (Protein, Mutant)IBA 07/2015
1	Histone Deacetylase InhibitorsIBA 08/2013
1	MC1568IBA 08/2013
1	nidoviral uridylate-specific endoribonucleaseIBA 10/2011
1	Polycomb Repressive Complex 2IBA 05/2011
1	Histone MethyltransferasesIBA 05/2011
1	Creatine Kinase (Creatine Phosphokinase)IBA 05/2011
1	ChromatinIBA 10/2010
1	Nitric Oxide Synthase (NO Synthase)IBA 10/2010
1	U1 small nuclear RNAIBA 09/2010
1	OligonucleotidesIBA 07/2010
1	Biological ProductsIBA 07/2010
1	placental protein 11IBA 12/2008
1	Serine Proteases (Serine Protease)IBA 12/2008
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2007
1	Phosphotransferases (Kinase)IBA 05/2007
1	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 05/2007
1	TropomyosinIBA 05/2007
1	Rhodopsin (Visual Purple)IBA 11/2006
1	Small Nuclear RNA (snRNA)IBA 03/2006

Therapy/Procedure

4	Therapeutics 02/2011 - 11/2006
1	Radiotherapy 05/2011